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The Big Picture San Diego Blog

Forge Therapeutics expands footprint in San Diego

March 13, 2018

On Monday, local leaders converged to celebrate a true San Diego success story: Forge Therapeutics. The biotech startup is doubling its local footprint and just became the newest tenant at Alexandria Real Estate’s Torrey Ridge Science Center.

World Trade Center San Diego and EDC first learned of Forge during its trade mission to the U.K. in October 2017. In London, CEO Zak Zimmerman announced a partnership with the U.K. team at Evotec, dubbed the BLACKSMITH platform. The international partnership allows Forge to work around the clock to brings its life-saving science to market.

In the U.S. alone, more than 23,000 die annually due to antibiotic-resistant bacteria, or ‘superbugs.’ Forge Therapeutics is changing that through the creation of a novel class of antibiotics that are targeting gram-negative bacteria, a class of bacteria with ‘bulletproof’ membranes that are resistant to traditional antibacterial interventions. The secret behind the life-saving science lies in metal-dependent enzymes or metalloenzymes. Zimmerman’s team has assumed the role of the blacksmiths of modern medicine; they are using chemistry to target these naturally occurring metals that help combat antibiotic-resistant superbugs.

Forge’s expansion comes at a time when telling the story of innovative, expanding companies is more important than ever.

"The national rhetoric around trade has not made it easy for businesses to create international partnerships, but supporting local companies as they expand overseas leads to economic growth and creates jobs here in San Diego. I hope that success stories, like Forge's and other groundbreaking companies in San Diego, can help change that," added Rep. Scott Peters, who was on site to provide remarks during the ribbon cutting.

San Diego already holds a reputation as a biotech powerhouse, but it’s true competitive edge lies in its ability to engineer and take life-saving treatments to market. San Diego civic leaders remained committed to fostering an environment where companies can continue to succeed.

By expanding its footprint and doubling its workforce, Forge is strengthening our city's reputation as a leader in medical research and innovation. Success stories like this demonstrate how important it is that we are creating the kind of environment where companies like this can grow and thrive," said San Diego Mayor Kevin Faulconer.

(Left photo: Mayor Faulconer receiving Forge-branded pitch fork from CEO Zak Zimmerman.)

But for Zimmerman and Forge, San Diego has been part of its DNA. Nearly three years ago, Zimmerman met UC San Diego professor Seth Cohen with a chance meeting on a soccer field. The initial technology for Forge was based on more than 15 years of leading research Cohen, spearheaded at UC San Diego. Much of the company’s funding and scientific board also has San Diego roots.

"We are extremely proud to be growing our footprint in San Diego. This biotechnology ecosystem consisting of groundbreaking science, educated investors, strategic advisors and local supporters has allowed us to thrive and expand in ways that we couldn't have imagined," Zimmerman said.

During a Fireside chat with San Diego Union-Tribune reporter Bradley Fikes, Zimmerman spoke a bit more about his decision to grow in San Diego. “Yeah, Boston and San Francisco are known for science, but we wanted to be in a place where people wanted to live and we can attract scientists with 10-20 years experience,” said Zimmerman.

Part of Forge’s growth is due to Alexandria Real Estate. Alexandria Investment Partners, the real estate company’s venture arm, backed Forge’s Series A. Now, they are providing Forge with more than 7,000 sq ft of office and lab space. But to Alexandria, it’s about creating an experience that helps companies foster life-saving innovation. “When you have a good feeling about your physical space, it makes you want to work hard,” said Zimmerman, of his new ARE office space.